Journal of Pathology and Translational Medicine

Case Study

Epithelioid Trophoblastic Tumor: Clinicopathologic and Immunohistochemical Analysis of Three Cases: Woo Jung Sung, Hyeong Chan Shin, Min-Kyung Kim, Mi Jin Kim; Korean J Pathol. 2013;47(1):67-73. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.67

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Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted of epithelioid intermediate trophoblastic cells that were mononucleated and eosinophilic, or showed clear cytoplasm on microscopic examination. One case presented with a focal choriocarcinoma component. Immunohistochemically, the tumors displayed diffuse positivity for cytokeratin 18, E-cadherin, epidermal growth factor receptor, and p53 and focal positivity for p63 and hCG. However, expression of α-inhibin and placental alkaline phosphatase was almost negative. Tests for human placental lactogen and epithelial membrane antigen were also negative in all cases.

Citations

Citations to this article as recorded by

Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab
David Pisani, Jean Calleja-Agius, Riccardo Di Fiore, John J. O’Leary, James P. Beirne, Sharon A. O’Toole, Ana Felix, Ian Said-Huntingford
Current Oncology.2021; 28(6): 5346. CrossRef
Epithelioid Trophoblastic Tumor
Stephanie M. McGregor, Larissa V. Furtado, Anthony G. Montag, Rebecca Brooks, Ricardo R. Lastra
International Journal of Gynecological Pathology.2020; 39(1): 8. CrossRef
Epithelioid trophoblastic tumor in a postmenopausal woman: A case report and review of the literature in the postmenopausal group
Seyran Yigit, Eylul Gun, Bulent Yilmaz, Zafer Kolsuz
Indian Journal of Pathology and Microbiology.2020; 63(5): 98. CrossRef
Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report
Kusum Jashnani, Alshifa Yagana, Niraj Mahajan
Indian Journal of Cancer.2020;[Epub] CrossRef
Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature
Chunfeng Yang, Jianqi Li, Yuanyuan Zhang, Hanzhen Xiong, Xiujie Sheng
Journal of Medical Case Reports.2020;[Epub] CrossRef
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy
Angiolo Gadducci, Silvestro Carinelli, Maria Elena Guerrieri, Giovanni Damiano Aletti
Gynecologic Oncology.2019; 153(3): 684. CrossRef
Diagnosis and Management of Mixed Gestational Trophoblastic Neoplasia: A Study of 16 Cases and a Review of the Literature
Yujia Kong, Guangshi Tao, Liju Zong, Junjun Yang, Xirun Wan, Wenze Wang, Yang Xiang
Frontiers in Oncology.2019;[Epub] CrossRef
A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors
Ka Yu Tse, Keith Wan Hang Chiu, Karen Kar Loen Chan, Mandy Man Yee Chu, Siew Fei Ngu, Annie Nga Yin Cheung, Hextan Yuen Sheung Ngan, Philip Pun Ching Ip
American Journal of Clinical Pathology.2018; 150(4): 318. CrossRef
MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report
Sakiko KAGEYAMA, Masafumi KANOTO, Yukio SUGAI, Takeshi SUTO, Satoru NAGASE, Mitsumasa OSAKABE, Takaaki HOSOYA
Magnetic Resonance in Medical Sciences.2016; 15(4): 411. CrossRef
Pharmacotherapy of placental site and epithelioid trophoblastic tumours
Fiona Taylor, Barry W Hancock
Expert Opinion on Orphan Drugs.2015; 3(1): 75. CrossRef
A Well-Circumscribed Border with Peripheral Doppler Signal in Sonographic Image Distinguishes Epithelioid Trophoblastic Tumor from Other Gestational Trophoblastic Neoplasms
Jiale Qin, Weiwen Ying, Xiaodong Cheng, Xiaodong Wu, Bingjian Lu, Yun Liang, Xinyu Wang, Xiaoyun Wan, Xing Xie, Weiguo Lu, Hai-Yan Lin
PLoS ONE.2014; 9(11): e112618. CrossRef

Case Reports

HER2-Positive Breast Carcinomas with Co-amplification or Gain of Chromosome 17 Centromere Locus: Report of Three Cases and an Impact on HER2 Testing.: Hyeong Chan Shin, Young Kyung Bae, Aeri Kim, Seok Ju Park; Korean J Pathol. 2011;45(6):665-669.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.6.665

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Abstract PDF: Recently we experienced three cases of human epidermal growth factor receptor 2 (HER2)-amplified invasive breast carcinomas associated with co-amplification or gain of chromosome 17 centromere (CEP17) in silver-enhanced in situ hybridization (SISH) analysis. These cases revealed 2+ or 3+ staining for HER2 immunohistochemistry and >6 HER2 copies per cell on SISH analyses. However, the calculated HER2/CEP17 ratios were low (<2.2) and did not fit within the HER2-positive category. We interpreted those cases as HER2-positive tumors based on the number of HER2 copies per cell. There is a potential for misinterpretation of SISH analysis in cases showing increased CEP17 copy number, based on the criterion used for HER2 positivity (HER2 copies >6 per cell vs HER2/CEP17 ratio>2.2). We recommend reporting raw SISH or fluorescence in situ hybridization data, including number of cells counted, average numbers of HER2 and CEP17 signals, and the calculated HER2/CEP17 ratio to prevent underreporting of HER2 amplification.

Ovarian Large Cell Neuroendocrine Carcinoma Associated with Endocervical-like Mucinous Borderline Tumor: A Case Report and Literature Review.: Jun Mo Kim, Hyeong Chan Shin, Mi Jin Kim; Korean J Pathol. 2011;45(5):523-528.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.5.523

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Abstract PDF

Ovarian large cell neuroendocrine carcinoma is a rare tumor that is usually associated with surface epithelial tumors. Mucinous tumors are most common surface epithelial component identified in reported cases. Ovarian mucinous tumor associated with large cell neuroendocrine carcinoma is almost always an intestinal type. However, large cell neuroendocrine carcinoma associated with pure mucinous borderline tumor of endocervical-like type has not been described previously. The present case report describes a large cell neuroendocrine carcinoma associated with endocervical-like mucinous borderline tumor of the ovary in a 35-year-old woman. The tumor was confirmed by histopathology and immunohistochemistry. A review of the pertinent literature is included.

Citations

Citations to this article as recorded by

The puzzle of gynecologic neuroendocrine carcinomas: State of the art and future directions
Giuseppe Caruso, Carolina Maria Sassu, Federica Tomao, Violante Di Donato, Giorgia Perniola, Margherita Fischetti, Pierluigi Benedetti Panici, Innocenza Palaia
Critical Reviews in Oncology/Hematology.2021; 162: 103344. CrossRef
Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature
Xiaohang Yang, Junyu Chen, Ruiying Dong
Journal of Ovarian Research.2019;[Epub] CrossRef
Primary pure large cell neuroendocrine carcinoma of the ovary
Chen-Hsien Lin, Yu-Chieh Lin, Mu-Hsien Yu, Her-Young Su
Taiwanese Journal of Obstetrics and Gynecology.2014; 53(3): 413. CrossRef
Pure Large Cell Neuroendocrine Carcinoma of Ovary: A Rare Clinical Entity and Review of Literature
P. N. Shakuntala, K. Uma Devi, K. Shobha, U. D. Bafna, M. Geetashree
Case Reports in Oncological Medicine.2012; 2012: 1. CrossRef

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